There is something wrong with the study of Uighur population genetics

in this paper “Genetic history of Xinjiang’s Uyghurs suggests Bronze Age multiple-way contacts in Eurasia” scientist assessed the genetic structure and ancestry of 951 Xinjiang’s Uyghurs (XJU) representing 14 geographical subpopulations. To understand the general patterns of relatedness between XJU and worldwide populations, they analyzed genome-wide data of XJU together with 203 worldwide populations from the Human Origins dataset (Lazaridis, et al. 2014). Reference populations were classified into five groups representing major geographical regions: Africa, America, Central Asia/Siberia (SIB), East Asia (EA), Oceania, South Asia (SA), and West Eurasia (WE) 

!!!which do not include Middle Eastern or Near Eastern population DNA data!!!

therefore their result did not fully represent modern Uyghurs admixture reality!!!

Figure 1        Genetic affinity and population structure of Xinjiang’s Uyghur (XJU).

Distribution map of XJU samples. The abbreviated name of each region was colored according to Fig. 1C. No samples were collected from Altay. 

Figure 2 Ancestry makeup and variations in admixture proportion within XJU. (A) ADMIXTURE results of XJU with West Eurasia, South Asia, East Asia, and Central Asia Siberia populations at K = 4 (in order to show a full picture of Eurasian populations, all populations of the four major ancestries (including representative populations) were included.). Proportion of each ancestry in XJU was highlighted with a pie chart. Height of the bar is proportional to admixture proportion. (B) Admixture proportions of the 4 major ancestries in regional XJU based on ADMIXTURE analysis in Fig. 2A. Red dashed line indicates the genetic barrier from EEMS analysis in Fig. 1D. (C) Correlations between proportions of 4 major ancestries and latitudes as well as longitudes of XJU across regions. Grey region indicate 95% confidence region for each regression fit. EA = East Asia; SA = South Asia; SIB = Siberia; WE = West Eurasia.

Figure 3 Population admixture and admixture history of XJU. (A) The most likely admixture topology of the 4 major ancestries in XJU based on Admixture History Graph (AHG) results. Ancestries represented as colored balls were as follows: EA (Red); SIB (Gold); EA-SIB (Plum); WE (Blue); SA (Green); WE-SA (Cyan). (B) Admixture time of EA-SIB admixture, WE-SA admixture, and West–East admixture in XJU by MultiWaver. Representative populations (represented as colored balls) used in MultiWaver were as follows: EA = Atayal; SIB = Nganasan; EA-SIB = Hezhen; WE = Sardinian; SA = Mala; WE-SA = Tajik_pomiri. Representative populations were 28 selected according to ADMIXTURE results with their major components (>10%) limited to representative ancestries. XJU from different regions in Xinjiang were inferred separately. (C) Schematic map showing the possible admixture model of XJU. Arrows in different colors indicate ancestral sources and directions of the gene flow.

Their result:

In XJU we identified 4 major ancestral components that were potentially derived from two earlier admixed groups: one from the West, harboring European (25%–37%) and South Asian ancestries (12%–20%), and the other from the East, with Siberian (15%–17%) and East Asian (29%–47%) ancestries. By using a newly developed method, MultiWaver, the complex admixture history of XJU was modeled as a two-wave admixture. An ancient wave was dated back to ~3,750 years ago (ya), which is much earlier than that estimated by previous studies, but fits within the range of dating of mummies that exhibited European features that were discovered in the Tarim basin, which is situated in southern Xinjiang (4,000–2,000 ya); a more recent wave occurred around 750 ya, which is in agreement with the estimate from a recent study using other methods. We unveiled a more complex scenario of ancestral origins and admixture history in XJU than previously reported, which further suggests Bronze Age massive migrations in Eurasia and East-West contacts across the Silk Road.

Now look at my DNA result!

Yes! I have 23.6% of Near Eastern ancestry! I strongly believe that there are millions of Uyghurs in Xinjiang are like me, we are mixed mainly five directions! not four directions! the paper ignored middle east! I read many papers about genetics of Uyghurs, no one compared Uyghurs with middle eastern population. why!? strongly why?!!!

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.